Growing Evidence Links Resveratrol to Extended Life Span

Growing Evidence Links Resveratrol to Extended Life Span

Since this initial report, resveratrol has continued to demonstrate extraordinary potential in prolonging life. In numerous studies resveratrol has demonstrated effects that mimic those of caloric restriction, the best-documented anti-aging strategy to date. In all animals in which it has been tested, caloric restriction—the practice of restricting calorie intake while maintaining good nutritional status—improves multiple aspects of age-related decline. Caloric restriction does this, in part, by producing changes in gene expression that are associated with long life and a slowing of the aging process.

Resveratrol is also gaining growing recognition for its promise in fighting age-related diseases ranging from dementia to diabetes. For example, the National Institute of Health is currently sponsoring a clinical trial investigating resveratrol’s ability to fight colon cancer.

RESEVERATROL AND CALORIC RESTRICTION

To date, the most reliable, best-researched way to extend life span is through the practice of caloric restriction, which involves reducing calorie intake while simultaneously maintaining good nutritional status.

In numerous studies, restricting calorie intake in laboratory animals has been shown to prolong their life span by as much as 60%.1-3 While scientists have not yet determined whether caloric restriction extends life span in humans, the preliminary evidence is very promising. In humans, consuming a low-calorie diet is associated with several possible markers of greater longevity, such as lower insulin levels and reduced body temperatures, along with less of the chromosomal damage that typically accompanies aging.4 Furthermore, people who consume a low-calorie diet may be less prone to diseases associated with being overweight or obese, such as metabolic syndrome, diabetes, cancer, and atherosclerosis.

Although caloric restriction may be effective in promoting longevity, the problem is that most adults find this stringent lifestyle strategy to be impractical. As a result, scientists have sought to uncover the precise mechanisms by which caloric restriction promotes longevity, in order to help people capture its life-extending benefits through more practical means.

RESVERATROL OFFSETS PERILS OF A HIGH-

CALORIE DIET

Remarkable new research suggests that it may be possible to achieve the life-extending benefits of caloric restriction using the readily available, plant-derived compound known as resveratrol. Resveratrol and caloric restriction appear to work via similar mechanisms to promote health and longevity in numerous animal species.

In an interview, a leading resveratrol researcher, Dr. Xi Zhao-Wilson of BioMarker Pharmaceuticals, told Life Extension, “There has been a great deal of attention focused on resveratrol in the past few years, following a study showing that resveratrol activates molecular pathways involved in life-span extension, now demonstrated in yeast, worms, flies, fish, and mice, and which possibly bear a relationship to mechanisms under-lying caloric restriction.”

This heightened interest in resveratrol has produced several recent breakthroughs. In a landmark study, Harvard University scientists showed that resveratrol could prolong survival by regulating a gene associated with aging that is present in all life forms.5 They demonstrated that while middle-aged mice fed a high-calorie diet suffered the ravages of obesity—including metabolic changes resembling diabetes, liver and heart damage, and premature death—mice that were fed resveratrol in addition to the high-calorie diet actually exhibited beneficial changes in their physiology, resembling those of mice fed a standard diet.5

Among the life-prolonging benefits of resveratrol supplementation demonstrated in the study were:

• increased insulin sensitivity
• lower blood sugar
• enhanced mitochondrial energy production
• improved motor function.

While mice on the non-supplemented high-calorie diet developed enlarged, fatty livers, resveratrol supplementation prevented these changes. Similarly, heart disease and evidence of atherosclerosis were seen in mice fed the high-calorie diet, but not in those that were also given resveratrol. Resveratrol significantly increased survival, reducing the risk of death from the high-calorie diet by 31%. Together, these findings offer powerful evidence that resveratrol protected the animals from the harmful effects of a high-calorie diet.5

Resveratrol’s positive impacts on insulin sensitivity and survival were apparent after only six months of treatment.5 Resveratrol also improved the animals’ quality of life, as reflected in their physical abilities. On a test of balance and coordination, the resveratrol-fed mice on the high-calorie diet steadily improved as they aged.5 The obese resveratrol-supplemented animals experienced all of these benefits without a significant reduction in body weight.5

“These data demonstrate that resveratrol can alleviate the negative impact of a high-calorie diet on overall health and life span,” the Harvard scientists concluded. “The ability of resveratrol to prevent the deleterious effects of excess caloric intake and modulate known longevity pathways suggests that resveratrol and molecules with similar properties might be valuable tools in the search for key regulators of energy balance, health, and longevity.”5

                         

MECHANISMS BY WHICH RESVERATROL MAY EXTEND LIFE

Today, scientists around the world are studying resveratrol to determine how it helps fight aging and prolong life span. Current evidence suggests that resveratrol exerts antioxidant effects, boosts energy production, and favorably alters patterns of gene expression.

Oxidative stress is implicated in numerous disease processes and in aging itself. Resveratrol demonstrates powerful antioxidant capabilities, with profound implications for human health. Scientists report that resveratrol inhibits the oxidation of dangerous low-density lipoprotein (LDL) and scavenges harmful hydroxyl radicals. Resveratrol also helps preserve levels of glutathione, one of the body’s most essential antioxidants.6According to prominent resveratrol investigator Dr. Milos Sovak, “There is no question that resveratrol is one of the best free-radical scavengers and that it has many effects whose ramifications might affect not only longevity but also general health.”

Resveratrol stimulates energy production in the cellular powerhouses known as the mitochondria. Diminished mitochondrial energy production is associated with reduced longevity. By enhancing the production of life-sustaining energy, resveratrol may help protect against metabolic disease and obesity, thereby improving health and prolonging survival in animals.7

Growing evidence indicates that resveratrol influences many genetic pathways, which may underlie its ability to lengthen life. In the recent Harvard study, investigators noted that a high-calorie diet produced numerous changes in gene expression. However, supplemental resveratrol opposed the effects of this high-calorie diet in 144 of 153 significantly altered genetic pathways. Moreover, resveratrol’s effects were dose dependent, with larger amounts yielding greater effects, leading the investigators to suggest that resveratrol may offer “new approaches for treating obesity-related disorders and diseases of aging.”7

Some of the genetic pathways influenced by resveratrol are similarly affected by caloric restriction. For example, caloric restriction is associated with long-term activation of AMP-activated kinase (AMPK), a metabolic enzyme promoting insulin sensitivity and fatty-acid oxidation. Resveratrol likewise increases AMPK activity, which is associated with life-span extension.5

Scientists believe that caloric restriction increases life span in part through its effects on the sirtuin genes.5 Present in all life forms, sirtuin genes are associated with aging and longevity. Resveratrol may confer benefits similar to those of caloric restriction by influencing the sirtuin gene known as SIRT2.5,8-10 In the Harvard study, resveratrol helped counteract changes in SIRT2 expression induced by a high-calorie diet.5

“The genes and pathways [affected by resveratrol or by caloric restriction] are related to activation of sirtuins, a class of histone deacetylase enzymes (HDACs) involved in cell death and life-span regulation,” Dr. Zhao-Wilson told Life Extension. “Based on the large body of evidence, the resveratrol/sirtuin activators have become the focus of pharmaceutical drug discovery efforts now [targeting] HDACs.”

Researchers believe that compounds like resveratrol that either activate or inhibit sirtuin activity may have therapeutic potential for a broad array of human diseases, including cancer, diabetes, heart failure, and neurodegenerative conditions such as Alzheimer’s and Huntington’s disease.11 

Specific Health Applications of Resveratrol

                         

CARDIOVASCULAR HEALTH

One of resveratrol’s most studied applications involves the prevention of cardiovascular disease. “The cardioprotective effects of resveratrol have been studied for years, based largely on the association of wine consumption with reduced risk of coronary heart disease,” notes Dr. Zhao-Wilson.

This plant-derived compound appears to act through several mechanisms to protect the cardiovascular system. Resveratrol may inhibit platelets from clumping together, thus reducing the risk of deadly blood clots that can lead to heart attack and stroke. 18-21 Furthermore, resveratrol helps improve blood flow by exerting beneficial effects on the linings of small blood vessels, known as the endothelium. This is a critical finding, since endothelial dysfunction is believed to underlie the progression of atherosclerosis.22-24

CANCER

In addition to its cardioprotective effects,25-27 resveratrol exhibits a range of anti-cancer properties.28 In laboratory cell studies, resveratrol has been found to inhibit the growth of numerous types of cancer, including leukemias, multiple myeloma, melanoma, and cancers of the breast, ovaries, prostate, stomach, colon, liver, pancreas, thyroid, uterine cervix, and head and neck.29,30

Resveratrol suppresses tumor growth by increasing or decreasing the production of various enzymes and molecules that regulate cellular reproduction and blood supply to the tumor.30,31 Through these mechanisms, resveratrol may enhance the anti-cancer effects of chemotherapeutic drugs and radiation.29 With its potent antioxidant capabilities,32,33 resveratrol may even protect healthy tissues from damage induced by chemotherapy. Since chemotherapy harms both healthy and cancerous tissues, this finding may have important applications in helping cancer patients tolerate its effects.34

Clinical trials in humans have shown that resveratrol has an excellent safety profile, and structural modifications of resveratrol with improved bioavailability are being studied as potential anti-cancer treatments.29

“Resveratrol is currently the subject of National Institutes of Health-sponsored clinical studies to evaluate its chemoprevention (cancer-preventive) effects,” according to Dr. Zhao-Wilson. An ongoing clinical trial at the University of California is studying resveratrol in patients with colon cancer.

INFLAMMATION AND ARTHRITIS

A common culprit in heart disease, cancer, and arthritis is chronic inflammation, mediated by naturally produced compounds in the body known as prostaglandins and cytokines. By blocking the activity of such inflammatory compounds, resveratrol may have therapeutic applications for all of these conditions.35,36

In a recently published study, scientists reported that resveratrol shows promise as a potential therapy for arthritis. When administered to animals with experimentally induced inflammatory arthritis, resveratrol protected cartilage against inflammatory changes related to the disease.37

NEUROPROTECTION

Resveratrol shows promise in protecting the brain and nervous system against disorders associated with aging and genetic factors. In laboratory studies, resveratrol’s antioxidant effect has been shown to protect against nerve cell damage caused by beta-amyloid peptide, which accumulates in the brains of Alzheimer’s sufferers.38-40 This has led several research teams to propose that resveratrol may be a useful treatment for Alzheimer’s disease.41-43

According to a recent report, resveratrol demonstrated a protective effect against Huntington’s disease in animal models.44 Huntington’s is a genetic disease associated with impaired motor skills and reduced mental abilities.

Additionally, grape seed extract appears to protect rat brain cells and maintain the overall viability of the nervous system. Grape seed exerts these effects by modulating proteins implicated in cognitive disorders.24

DIABETES

Resveratrol may offer benefits in preventing or managing conditions associated with high blood sugar, such as metabolic syndrome or diabetes. Sirtris Pharmaceuticals, a company founded by Dr. David Sinclair, leader of the Harvard resveratrol study, is conducting a clinical trial to evaluate resveratrol’s effects in controlling blood sugar in patients with diabetes.

EXTENDING HUMAN LIFE SPAN

Based on his study of experimental life-span extension in mice,45 Dr. Richard A. Miller of the University of Michigan suggests that resveratrol may extend the human life span.

Dr. Miller speculates that with effects similar to those of caloric restriction, resveratrol could extend human longevity to about 112 or even 140 years of healthy life.

Practical Considerations for Optimal 

Supplementation

While plentiful data attest to resveratrol’s potential benefits for health and longevity, certain practical concerns must be addressed to obtain its optimal effects as a dietary supplement. These include resveratrol’s stability, shelf life, dosage, and the variability of different available preparations. Even today, much remains to be learned about the pharmacokinetics of resveratrol—that is, how it is absorbed, utilized, broken down, and excreted in humans.

BIOAVAILABILITY

Laboratory and animal studies clearly show that resveratrol and its derivatives are biologically active. However, Dr. Zhao-Wilson notes that there are “significant issues related to what is currently known about resveratrol’s bioavailability—it appears to be rapidly metabolized in humans.” Dr. Sovak agrees, commenting, “One problem with resveratrol is that we do not know that much about its resorption and bioavailability in humans, but as expected, the compound is rapidly metabolized and excreted.”

Scientists are exploring ways to optimize resveratrol’s pharmacokinetics. For example, in the Czech Republic, where resveratrol has been approved as a nutritional supplement, Dr. Sovak and his colleagues conducted a pilot study in humans comparing high-purity, pharmaceutical-grade resveratrol to resveratrol glycon, the natural form of resveratrol extracted from the Polygonum plant. Of the two preparations, resveratrol glycon was found to be more easily absorbed in the body and to have better pharmacokinetics.

Another method under investigation to improve resveratrol’s bioavailability is administering it concomitantly with plant-derived flavonoids. Numerous studies suggest that the bioflavonoid quercetin slows the inactivation of resveratrol, thus improving its bioavailability.46,47 A novel type of quercetin, quercetin chalcone, demonstrates superior absorption and solubility, and may thus be the optimal form of this bioflavonoid.48

                         

STABILITY

Previously, scientists were concerned that the clinical usefulness of certain resveratrol-encapsulated preparations could be limited by poor stability, limited shelf life, or exposure to light and air. However, recent stability studies by Dr. Sovak and his colleagues at the Czechoslovak company Interpharma Praha have demonstrated these concerns to be unjustified. Resveratrol is generally stable for at least two years and does not require special packaging or storage.49

PURITY

Not all resveratrol preparations are of equal quality. “As for the variability of different available preparations, this is always an issue with respect to manufacturing and quality control associated with dietary supplements in general,” says Dr. Zhao-Wilson. “It is ‘buyer beware,’ and one must find a high-quality source with a vested interest in providing consumers with the best available products and scientific evidence to back them up.”

DOSAGE

In addition to exploring resveratrol’s many potential health applications, researchers are also trying to determine the optimal dose needed to capture its benefits.

“There have been insufficient studies to date in humans to address issues related to optimal dose,” notes Dr. Zhao-Wilson. “Extrapolation of optimal dose from animal studies to humans is always more of an art than a science, and the appropriate studies still need to be done. Nevertheless, reasonable assumptions can be made, and there is even evidence that low doses may be effective for certain conditions.”

Many commercially available supplements provide 20 mg of resveratrol daily. The rationale behind this dosage is that prior to the widespread use of pesticides, French red wine contained approximately 20 mg of resveratrol per liter, and those drinking about a liter daily appeared to derive the cardioprotective benefit associated with the French paradox. Now that the resveratrol content in red wine has decreased to 90 micrograms per fluid ounce,50 a 20-mg (20,000-mcg) resveratrol supplement contains approximately 220 times the amount of resveratrol in one fluid ounce of red wine, or about 41 times the amount in one glass of red wine.

Studies by BioMarker have shown that resveratrol offers benefits for gene expression and longevity in a variety of species using a dosage comparable to 20 mg daily in humans. However, given the extraordinary findings of recent studies using high-dose resveratrol supplements—and their profound implications for human health—some resveratrol researchers and other health-conscious people are now consuming even larger daily dosages.

As for who should supplement with resveratrol, leading researchers maintain that in addition to benefiting patients with specific disease conditions, resveratrol may confer broad-spectrum protection to anyone seeking to live a long life in optimal health.

According to Dr. Zhao-Wilson, “the properties associated with resveratrol appear to be largely protective—cardioprotective, neuroprotective, anticarcinogenic, anti-inflammatory—and the current data suggest that most people could benefit from dietary supplementation with resveratrol obtained from a high-quality source.” Dr. Zhao-Wilson adds that resveratrol is generally safe when taken in conventional dosages.

Dr. Sovak similarly recommends resveratrol as a health-protective agent, noting that resveratrol may be helpful both alone and in combination with other antioxidants, such as epigallocatechins derived from green tea.51,52

RESVERATROL AND EXTENDED LIFE SPAN: WHAT YOU NEED TO KNOW

Resveratrol, a health-promoting compound found in grapes, has been shown to increase life span in several animal species. In a recent Harvard study, mice that consumed a high-calorie diet known to shorten life lived longer when they also consumed resveratrol. These mice also had better coordination, less heart and liver damage, and better insulin sensitivity than overweight mice that were not fed resveratrol. Scientists have proposed that resveratrol in red wine may help explain the “French paradox”—the fact that cardiovascular disease rates in France are relatively low, despite a diet traditionally high in fat. Because widespread use of pesticides has diminished the amount of resveratrol contained in grapes and red wine, supplemental resveratrol may the best way to ensure optimal intake. Laboratory and animal studies suggest that resveratrol may have therapeutic potential for cardiovascular disease, cancer, inflammatory arthritis, Alzheimer’s disease, and other neurodegenerative conditions. Clinical trials studying resveratrol’s effects on cancer and diabetes are also under way. Resveratrol may enhance health and support longevity via several mechanisms. These include its potent antioxidant effects, ability to enhance cellular energy production, and ability to influence patterns of gene expression in a manner similar to caloric restriction (the best-documented method of extending life span in animals). Because resveratrol exerts protective effects through a variety of mechanisms, it may be a useful supplement for healthy adults wishing to reduce their risk of chronic disease and live a long and healthy life. Studies to date suggest that resveratrol is safe and nontoxic.

References for "Growing Evidence Links Resveratrol to Extended Life Span"

1. Ingram DK, Anson RM, de Cabo R, et al. Development of calorie restriction mimetics as a prolongevity strategy. Ann NY Acad Sci. 2004 Jun;1019:412-23.2. Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev. 2005 Sep;126(9):987-1002.3. Valenzano DR, Terzibasi E, Genade T, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300.4. Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA. 2006 Apr 5;295(13):1539-48.5. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.6. Available at: http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/res_0224.shtml. Accessed January 10, 2007.7. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.8. Kaeberlein M, McDonagh T, Heltweg B, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17038-45.9. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-95.10. Guarente L, Picard F. Calorie restriction—the SIR2 connection. Cell. 2005 Feb 25;120(4):473-82.11. Porcu M, Chiarugi A. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol Sci. 2005 Feb;26(2):94-103.12. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997 Oct;8(10):645-9.13. Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol. 2002;505:95-111.14. Bujanda L, Garcia-Barcina M, Gutierrez-de JV, et al. Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. BMC Gastroenterol. 2006 Nov 14;6:35. 15. Sovak M. Grape extract, resveratrol, and its analogs: a review. J Med Food. 2001;4(2):93-105.16. Ignatowicz E, Baer-Dubowska W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol J Pharmacol. 2001 Nov;53(6):557-69.17. Fremont L. Biological effects of resveratrol. Life Sci. 2000 Jan 14;66(8):663-73.18. Bhat KPL, Kosmeder JW, Pezzuto JM. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64.19. Wang Z, Huang Y, Zou J, et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med. 2002 Jan;9(1):77-9.20. Olas B, Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thromb Res. 2002 Apr 15;106(2):143-8.21. Olas B, Wachowicz B, Saluk-Juszczak J, Zielinski T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb Res. 2002 Aug 15;107(3-4):141-5.22. Brito PM, Mariano A, Almeida LM, Dinis TC. Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione. Chem Biol Interact. 2006 Dec 15;164(3):157-66.23. Novakovic A, Bukarica LG, Kanjuh V, Heinle H. Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol. Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):360-4.24. Kim H, Deshane J, Barnes S, Meleth S. Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds. Life Sci. 2006 Mar 27;78(18):2060-5.25. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch Biochem Biophys. 2007 Jan 1;457(1):1-6.26. Goh SS, Woodman OL, Pepe S, et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxid Redox Signal. 2007 Jan;9(1):101-13.27. Chen WP, Su MJ, Hung LM. In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. Eur J Pharmacol. 2007 Jan 12;554(2-3):196-204.28. Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutat Res. 2003 Feb;523-524:145-50.29. Aggarwal BB, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep;24(5A):2783-840.30. Trincheri NF, Nicotra G, Follo C, Castino R, Isidoro C. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis. 2006 Nov 20.31. Heynekamp JJ, Weber WM, Hunsaker LA, et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor KappaB. J Med Chem. 2006 Nov 30;49(24):7182-9.32. Vigna GB, Costantini F, Aldini G, et al. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism. 2003 Oct;52(10):1250-7.33. Vinson JA, Proch J, Bose P. MegaNatural((R)) gold grapeseed extract: in vitro antioxidant and in vivo human supplementation studies. J Med Food. 2001;4(1):17-26.34. Olas B, Wachowicz B, Majsterek I, et al. Antioxidant properties of trans-3,3’,5,5’-tetrahydroxy-4’-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compounds. Nutrition. 2006 Nov;22(11-12):1202-9.35. Martin AR, Villegas I, La CC, de la Lastra CA. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol. 2004 Apr 1;67(7):1399-410.36. Richard N, Porath D, Radspieler A, Schwager J. Effects of resveratrol, piceatannol, tri-acetoxystilbene, and genistein on the inflammatory response of human peripheral blood leukocytes. Mol Nutr Food Res. 2005 May;49(5):431-42.37. Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation. 2006 Nov 4.38. Savaskan E, Olivieri G, Meier F, et al. Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology. 2003 Nov;49(6):380-3.39. Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82.40. Wang J, Ho L, Zhao Z, et al. Moderate consumption of cabernet sauvignon attenuates abeta neuropathology in a mouse model of Alzheimer’s disease. FASEB J. 2006 Nov;20(13):2313-20.41. Anekonda TS. Resveratrol—a boon for treating Alzheimer’s disease? Brain Res Brain Res Rev. 2006 Sep;52(2):316-26.42. Luo L, Huang YM. Effect of resveratrol on the cognitive ability of Alzheimer’s mice. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Aug;31(4):566-9.43. Sharma M, Gupta YK. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 2002 Oct 11;71(21):2489-98.44. Kumar P, Padi SS, Naidu PS, Kumar A. Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms. Behav Pharmacol. 2006 Sep;17(5-6):485-92.45. Harper JM, Salmon AB, Chang Y, et al. Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev. 2006 Aug;127(8):687-94.46. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica. 2000 Sep;30(9):857-66.47. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica. 2000 Jun;30(6):609-17. 48. Hayashi A, Gillen AC, Lott JR. Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice. Altern Med Rev. 2000 Dec;5(6):546-52.49. Prokop J, Abrman P, Seligson AL, Sovak M. Resveratrol and its glycon piceid are stable polyphenols. J Med Food. 2006;9(1):11-4.50. Available at http://www.news.cornell.edu/releases/Feb98/Resveratrol.bpf.html. Accessed January 18, 2007.51. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006 Jan 15;66(2):1234-40.52. Rezai-Zadeh K, Shytle D, Sun N, et al. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein  cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci. 2005 Sep 21;25(38):8807-14.

Source: "Life Extension Magazine" (Spring 2007) Best Resveratrol  Product I use

Mangosteen Extract - from "Queen of Fruits"

Mangosteen Extract - from "Queen of Fruits"

Mangosteen Fruits, a tropical fruit famous as the "Queen of Fruits", is one of the most nutrient-rich plant foods on Earth, in which containing the compounds called Xanthones with biological active plant phenols structurally similar to flavonoids, which is thought to have antioxidant properties; which also a rich source of other bioactive molecules including flavenoids, benzophenones, lactones, phenolic acids, vitamins, minerals, amino acids, and also contain such nutrients as well as zinc, iron, copper, calcium, germanium, etc.

The Xanthones have been known as unique, biologically active group of molecules processing a six-carbon conjugated ring structure with multiple double carbon bonds, in Mangosteen including: 1,6-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl) xanthone, 1,5,8-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl) xanthone, maclurin, 1,3,6,7-tetrahydroxy xanthone, 1,3,6,7-tetrahydroxy xanthone-O-.beta.-D-glucoside, chrysanthemin, cyaniding-3-O-.beta.-D-sophoroside, 8-deoxygartanin, 1,5-dihydroxy-2-isopentenyl-3-methoxy xanthone, 1,7-dihydroxy-2-isopentenyl-3-methoxy xanthone, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)2(H), 6(H)-pyrano-(3,2,6)-xanthen-6-one, fructose, garcinone A,B,C, D and E, gartanin, glucose, cis-hex-3-enyl acetate, 3-isomangostin, 3-isomangostin hydrate, 1-isomangostin, 1-isomangostin hydrate, kolanone, mangostin, beta.-mangostin, alpha.-mangostin, mangostin-3,6-di-O-gulcoside, normangostin, sucrose, tannins, BR-xanthone-A, BR-xanthone-B, calabaxanthone demethylcalabaxanthone,2-(.gamma.,.gamma.-dimethylallyl)-1,7-dihydroxy-3-m ethoxyxanthone, 2,8-bis-(.gamma.,.gamma.-dimethylallyl)-1,3,7-trihydroxyxanthone, 1,3,5,8-tetrahydroxy-2,4-diprenylxanthone, and mangostanol.

Since the first scientific article on the mangosteen's function properties was written by Jaques Garcin in 1697, researches in 11 different countries investigating Mangosteen fruits for its function properties have produced over 50 published scientific papers. In most instances, the research was initiated to elucidate the mechanisms behind the mangosteen for it's new function claims:

Antioxidant protection against free radicals Maintains immune system health Promotes joint flexibility Provides positive mental support Reduces allergies Reduces joint inflammation Prevents cancer Pain control -sciatica and radicular pain syndromes

*Berry Blast Green Cuisine with Mangosteen has a great tasting energizing and phytonutrient powder mix loaded with certified organic whole foods and plant extracts. It supplies a blend of completely natural vitamins, ionic minerals, enzymes, antioxidants and symbiotic intestinal flora.

ESTROGEN MAY AMPLIFY STRESS

BY WILLIAM HATHAWAY THE HARTFORD COURANT

The combination of estrogen and stress may make women more susceptible to anxiety and depression than men, a study by researchers at the Yale University School of Medicine suggests.

The study was one of the first attempting to find a molecular reason why women are about twice as likely to experience major depression and anxiety disorders as men, said Rebecca Shansky, a graduate student in Yale’s neurobiology department and lead author of the study, published in the March issue of the journal Molecular Psychiatry.

“People really haven’t studied this in a gender-specific way,” Shansky said. Stress has been implicated in the development of major depression, a condition marked by disruption in the prefrontal cortex.

This area of the brain regulates behavior, thought and working memory — the ability to plan and organize behavior.

Shansky and other Yale neuro-biologists decided to place rats under stress to gauge the influence estrogen levels have on the rats’ ability to complete simple memory tasks.

Without any stress, male and female rats performed memory tasks equally well.

With high levels of stress, male and female rats both made a lot of errors. However, male rats performed significantly better at memory tasks than females when placed under moderate stress.

On closer study, researchers discovered that female rats performed poorly on the tests only during proesterus, when they produced high levels of estrogen.

During estrus, or with low estrogen levels, there was no impairment.

The scientists then removed the ovaries of female rats and repeated the experiment, giving some rats estrogen replacement and other placebos.

Again, they found that female rats with high levels of estrogen performed worse on memory tasks than those without.

The results suggest that estrogen may amplify the negative effect of stress on the brain’s ability to complete certain tasks, Shansky said.

It could be that estrogen also increases susceptibility to stress-related disorders, such as depression and anxiety, which would help explain why the increased risk ends at menopause, she said.

However, Shansky said estrogen may have beneficial effects on other areas of the brain and on other functions — such as long-term memory formation.

“It is important that this study isn’t presented as saying estrogen is bad for women,” Shansky said.

Dr. Nick Martinis, assistant professor of psychiatry at the University of Connecticut Health Center, said estrogen can have some beneficial effects on the serotonin system, which often malfunctions in depressed patients.
DeMartinis speculated that in some women the combination of high levels of stress and estrogen interferes with serotonin regulation and triggers depression.

Teasing out female-specific contributing factors may have great value in developing new treatments for anxiety and depression, DeMartinis said.

“There may be ways to treat depression that are more helpful to women than men, but we haven’t found them yet,” he said. “When we figure that out, we may be able to customize those treatments.”

A PRODUCT ALL WOMEN SHOULD BE ON.

ALOE VERA PLANT'S POLYMERS ARE FOUND TO IMPROVE BLOOD FLOW

ALOE VERA PLANT'S POLYMERS ARE FOUND TO IMPROVE BLOOD FLOW PITT RESEARCHER'S RESULTS OFFERTANTALIZING IMPLICATIONS

For some people, cultivating an aloe vera plant is like having a first aid kit on the windowsill. In case of a minor burn or cut, they break off a leaf and use the clear, slick gel oozing from its center as an ointment. Surveying the array of aloe plants with broken, stubby leaves growing in the window of Marina Kameneva's laboratory, one might become concerned about the safety of the students working there. But her lab isn't an unusually hazardous place and her lab workers aren't particularly accident-prone. Rather, the plants are regularly harvested because the aloe gel contains polymers that Kameneva says improve blood flow. Adding a minute amount of these polymers to the blood makes it easier to pump and improves its ability to squeeze through the tiny arteries and capillaries where red blood cells do their work ---- supplying cells with oxygen and removing carbon dioxide. Kameneva, a bioengineer who directs the artificial blood program at the University of Pittsburgh's McGowan Institute for Regenerative Medicine, discovered these drag-reducing polymers in aloe gel several years ago. She believes they eventually might be used to treat a number of medical conditions, including heart attacks, stroke and circulation problems associated with chronic conditions such as diabetes and peripheral vascular disease. "It's quite a remarkable discovery," said Dr. Mitchell Fink, chairman of critical care medicine at the University of Pittsburgh School of Medicine. In a study published in this month's issue of the journal Shock, he and Kameneva found that rats that suffered severe blood loss were five times more likely to survive this hemorrhagic shock if treated with the aloe vera-derived polymer. "It's potentially applicable to a whole host of conditions," said Fink, who noted this small animal study in a relatively obscure journal already has generated a lot of buzz. "I've gotten e-mails from all over the place." As of yet, no one understands precisely how these polymers manage to improve blood flow. But the same thing also can be said for drag-reducing polymers in general. Reducing turbulence First described following World War II by British chemist B.A. Toms, drag-reducing polymers reduce turbulence when added to fluids. That allows fluids to be pumped with less pressure or, under constant pressure, to flow at a greater rate. This concept of cutting resistance by reducing turbulence is the same approach used by automobile designers, noted Guy Berry, a chemistry professor at Carnegie Mellon University. By streamlining or by adding airfoils, car designers smooth the flow of air over the vehicle, reducing turbulence and thus helping the vehicle slice through the air. "It was very exciting when it was first observed," Berry recalled of the discovery of drag-reducing polymers. They have been used to ease the flow of oil in the Alaskan pipeline, to increase well pressures for enhanced oil recovery and, in firefighting, to make water shoot farther from fire hose nozzles. The U.S. Navy has long been interested in using drag-reducing polymers to help submarines and surface ships move with greater stealth and less power. Charles McCormick, a polymer scientist at the University of Southern Mississippi, once worked on a project for the Defense Advanced Research Projects Agency to use the polymers to reduce friction on torpedoes. In a bit of serendipity, the British Navy once discovered that algae in water tanks it used to test ship models were producing a polysaccaride that was reducing turbulence, McCormick said. For a time, British scientists tried, without success, to get the algae to grow on ship hulls. But how turbulence is reduced is not fully understood. Drag-reducing polymers, whether naturally occurring or manmade, tend to be very long and relatively stiff molecules. Many polymers tend to coil back on themselves, Berry said, but drag-reducing polymers look more like uncooked spaghetti. It appears that the length of the polymers is related to the size of microturbulent eddies in liquids, McCormick said. This seems to keep waves from propagating from the eddies, reducing turbulence. At least that's one theory. But when it comes to how drag-reducing polymers work in blood, things get even murkier. Blood flowing through blood vessels is not turbulent, said Kameneva, who began studying drag-reducing polymers 30 years ago at Moscow State University in Russia. Kameneva and her mathematician husband, Boris Kushner, were among thousands of Soviet Jews who fled the foundering Soviet Union in the late 1980s. They moved to Pittsburgh in 1989 and Kameneva joined Pitt in 1991. She had suspected that aloe gel, known to be rich in polysaccarides, might contain drag-reducing polymers. An earlier researcher, she noted, had already shown that polysaccarides derived from okra improved blood circulation. She found the aloe-derived polymers made blood more slippery, helping it move from larger arteries to increasingly narrow pre-capillary vessels and capillaries. Also, as vessels continually branch off, the polymers seem to reduce the tiny vortexes that form at each bifurcation, she said. Normally, a very thin layer -- 4 to 5 microns -- of blood plasma coats the lining of the blood vessels, keeping the red blood cells away from the wall. But the drag-reducing polymers thin this plasma layer further, allowing the blood cells to come closer to the wall, making gas exchange easier. As the red blood cells get closer to the vessel walls, they experience more shear stress, stretching out the cells and exposing more of their surface to the vessel wall. The proximity of the cells to the vessels also triggers the production of nitric oxide, which causes the vessels to dilate. These effects would be important in the treatment of hemorrhagic shock, which occurs following the loss of blood. Standard treatment is to stop the bleeding and to restore blood volume by adding liquid called Ringer's solution and red blood cells. But even if blood volume is restored, the microcirculation at the capillary and pre-capillary level can remain impaired, particularly if the low blood volume has persisted for a long time. "That's why [hemorrhagic shock] patients die from organ failure," Kameneva said. The polymers improve microcirculation, by dilating the vessels, making the red blood cells work harder and by increasing blood pressure. "If you have higher blood pressure, it can push more blood cells through" the tiny vessels, she explained. Battlefield applications? The recent rat study of shock was sponsored by DARPA to test whether a small amount of polymer could keep battlefield victims alive another hour or two while they are evacuated. It's impossible for medics to carry sufficient fluids to infuse shock victims, but they could carry enough polymer to treat a number of patients. The study thus focused on whether the polymers could serve as an alternative to fluid infusions. But Fink said treatment for hemorrhagic shock remains problematic even when intravenous fluids are readily available, so further study of the polymers as an addition to standard therapy would be justified. Fink said the polymers don't seem to have any safety problems, but cautioned that the polymers have yet to undergo the sort of safety testing in animals that would be necessary before they could be considered for testing in humans. Also, Kameneva has yet to determine the exact composition of the drag-reducing polymer. That information would be necessary before the Food and Drug Administration would consider approving it as a drug and also would be needed to patent it, Fink said. Without a patent, he added, no pharmaceutical company would be willing to make the investment necessary to allow clinical trials, much less bring the drug to market. Kameneva said the composition of aloe gel has been widely studied, but which of the polysaccarides in the gel are incorporated in the polymer and in what sequence is not known. "I'm not a chemist," she explained. One of her graduate students, Joie Marhefka, is analyzing the polymer's structure, she said, but an expert in polysaccaride chemistry probably could determine the structure in two or three months. Kameneva hopes that as more people learn about the potential of her polymer she might find a chemist interested in collaborating or an industrial sponsor willing to bankroll such a study. Her experience thus far, however, has been that drag-reducing polymers are a concept that many medical researchers have a hard time comprehending. "It took me four years here to publish the first paper," she said, admitting she has been frustrated at times by the pace of her progress. "It's still in the laboratory and it's a shame."

More info about Aloe

All Natural StressRelief

In today’s busy lifestyle, stress is not an option. We all experience it to some degree. Do you find yourself snapping at your kids, your spouse, or your co-workers? Do you get irritated quickly? Does it seem like small things “set you off”? Stress is often characterized by fatigue, sleep disorders, irritability and constant worrying. Depression often accompanies stress. The accumulated effects of stress may prevent us from living life to its fullest and may lead to more serious medical conditions.

Total Image StressRelief is an all-natural herbal formula containing St. John’s Wort. St. John’s Wort is actually prescribed in other countries by doctors for anxiety and depression. Our StressRelief formulation is a safe alternative to prescription drugs to combat the stress we all face. Some people call it their “happy pill” because it helps them deal with the difficulties in their life. Aren’t you ready to try it today? Click here!

Whey Protein

High Quality Protein, Lactose Free, Bio-available. Great Natural Source of High Potency Essential Amino Acids. The muscles in your body are over 80% protein in dry weight. If your goal is an increase of muscle, then do it with Entrenet Whey. The ion-exchanged whey protein in this product is the most bio-available for your body. This means your body can utilize the supplementation of Entrenet Whey better than other types of protein. Entrenet Whey is also low in calories, low in carbs and high in protein. It tastes great and mixes well with water, juice or milk. Entrenet Whey is also lactose free with no added sodium. Entrenet Whey can be used as a meal replacement.

Ingredients: Ion Exchange Whey, Natural Flavors and Natural Sweetner Stevia. NO SUGAR OR

ASPARTAME ADDED. 18 Amino Acids

L-alannine	563mg
L-arginne	794mg
L-aspartic Acid	1294mg
L-cystine	75mg
L-histidine	574mg
L-isoleucine	893mg
L-leucine	1747mg
L-lysine	1444mg
L-methionine	564mg
L-phenylalanine	957mg
L-proline	1970mg
L-serine	1188mg
L-threonine	807mg
L-tryptophan	225mg
L-tyrosine	1132mg
L-valine	1069mg
L-glutamic Acid	3989mg
L-glycine	388mg

AVAILABLE IN: CHOCOLATE & VANILLA

More Info Click Here

COMPLETE FOOD SUPREME

COMPLETE FOOD SUPREME has been formulated with five essential supplements blended together into one comprehensive or “Complete” formula. Each capsule contains all of the five components: a Vitamin-Mineral component, a Calcium Mineral Component, an Antioxidant component, a Fish Oil component rich in Omega-3 fatty acids and a Phytonutrient component. Each of these components addresses separate, specific needs of your body.

COMPLETE FOOD SUPREME is one of the best, most “complete” daily supplements available. Each of the five components addresses specific daily needs in supporting your body's optimum health, healing and performance. The Vitamin and Mineral components provide your body with many of the nutrients recognized as esential in your diet as put forth in the Reference Daily Intake (RDI). The Antioxidant component supports your body's fight against harmful free-radicals which can cause cellular damage. The Calcium Mineral component naturally contains every mineral found in the human body in similar proportions to the human body, with all 74 individual minerals being highly absorbable. The Fish Oil component rich in two kinds of Omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) provide nutritional support for heart health of healthy people, people at high risk of cardiovascular disease and those with cardiovascular disease. The Phytonutrient component provides specific nutrients found in plants that have been shown to provide health benefits by supporting the body's functioning and maintenance of optimum health. Each of these components is important in its own way, but together they provide your body with "Complete" nutriition.
Suggested Usage: As a dietary supplement for adults. Take 1 to 2 packets a day with meals.
VITAMINS - PHYTONUTRIENTS in Complete Food

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COMPONENT #1
CATECHINS (green tea) – Inhibits the growth of cancerous tumors and blood cholesterol.
GENISTEIN (soy) – Inhibits growth of breast and prostate cancer cells and has been shown to convert abnormal cancer cells into normal ones ending the spread of cancer.
CAPSICUM (hot pepper) – Lowers cholesterol and triglycerides, helps prevent formation of blood clots that lead to heart attack or stroke.
ELLAGIC ACID (grapes) – Counteracts synthetic and naturally occurring carcinogens preventing healthy cells from turning cancerous.
INDOLES (cruciferous vegetables) – May inactivate potent estrogens that stimulate the growth of tumors.
LYCOPENE (tomatoes) – Antioxidant recent studies suggest that it may protect against cervical cancer.
SULFIDES (garlic, onions) – Daily reduces metabolism of nitrosamine, a potent naturally occurring carcinogen by the liver.
QUERCETIN (onions, broccoli) – Inhibits growth of tumor cells containing binding sites for type 2 estrogen-breast cancer.
D-LIMONENE (orange and lemon peel) – Can inhibit growth of breast cancer cells in animals and programs breast cancer cells in rats to self-destruct.
SULFORAPHANE (cruciferous vegetables) – Stimulates cells.
PHYTOESTROGEN – Natural estrogen that protects body against hormonal estrogens.

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COMPONENT #2
VITAMIN A (beta carotene and palmitate) – Promotes the growth of healthy cells. Helps prevent eye problems.
VITAMIN C (ascorbic acid, calcium ascorbate) – This is a powerful antioxidant that is necessary for the health of all the connective tissue in the body. A natural antibiotic that builds the immune system while it fights colds, flu, cancer, fatigue, and repairs tissue. Vitamin C decreases cholesterol, protects against blood clots, and strengthens the circulatory system. This helps prevent bruising and is a must for healthy bones and teeth.
VITAMIN E (d-alpha tocopheryl sucinate with beta, gamma, and delta tocoperol) – Excellent for circulation, is an antioxidant and protects red blood cells. It is useful in tissue repair, pms, and treating fibrocystic breasts. It helps reduce blood pressure and slows down cellular aging. Vitamin E is only stored in the body for a short time. Alpha-tocopherol is the most effective type of Vitamin E. It supports the activity of Vitamin A. It also provides more energy to the blood by supplying oxygen.
VITAMIN B1 (thiamin mononitrate) – Helps with the production of hydrochloric acids that are needed for digestion. Enhances circulation and aids carbohydrate metabolism. It aids in the treatment of shingles and improves mental attitude.
VITAMIN B2 (riboflavin, riboflavin 5 phosphate) – This is a common deficiency and important for growth and antibody production. Helps skin, nails and hair. Helps eye strain and prevention of cataracts.
VITAMIN B3 (niacinamide) – Aids in digestion and proper utilization of nutrition. Improves circulation to the brain.
VITAMIN B6 (pyridoxine hydrochloride, pyridoxal 5 phosphate)– This is important for your physical and mental health. Pyridoxine helps with water retention and helps maintain the sodium and potassium balance in the body. Aids in digestion and helps the immune system. Pyridoxine reduces the formation of cholesterol around the heart muscle. Helps in preventing kidney stones and pms. A deficiency is linked to carpal tunnel.
FOLIC ACID – This is necessary for energy production. It aids in protein metabolism and the formation of red blood cells. It also helps to improve lactation. Good for preventing parasites in the intestinal tract.
PANTOTHENIC ACID (d-calcium pantothenate) – Recommended for glaucoma, aids in healing, fights infection. Called the antistress vitamin, is important in the production of the adrenal hormones and antibodies. This is required by all cells of the body and aids in vitamin utilization.
VITAMIN B12 (cyanocobalamin) – Necessary for proper digestion, protein synthesis, and cellular longevity. Necessary to prevent anemia, aids in cell formation, prevents nerve damage and supports normal growth. Many older folks have Vitamin B12 deficiency because of malabsorption.
BIOTIN – This is necessary for normal metabolism of fat and protein. It has been helpful to slow down the loss of hair and graying.
CALCIUM (carbonate) – Maintains strong bones and teeth. It keeps the heart beating regularly, metabolizes body iron, and is a natural sedative. It is essential for a healthy nervous system, blood clotting, and helps in the prevention of colon cancer.
MAGNESIUM (oxide) – It is important to enhance enzyme activity and for effective nerve and muscle function. Helps convert blood sugar to energy. Prevents depression and stress. A deficiency can cause irritability, high blood pressure, muscle weakness, dizziness and heart disease.
COPPER (chelate) – Essential to the formation of hemoglobin in red blood cells and bone. It is necessary for healthy nerves and energy production. Needed for healthy protein and enzyme formation.
IRON (citrate) – Essential in the formation of red blood cells, promotes disease resistance and improves skin tone. Iron deficiency causes hair loss, dizziness and anemia. Women lose twice as much iron as men.
MANGANESE (citrate) – For healthy nerve and immune system, improves blood sugar regulation. Necessary for healthy bones, fights fatigue, improves memory and reduces irritability. Helps lactation and produces enzymes needed to oxidize fats.
ZINC (chelate) – This mineral builds and supports the immune system. It is involved in protein synthesis, formation of insulin, helps normalize the prostate and helps restore smell and taste loss. Recommended for healing skin and acne. It accelerates healing and promotion of growth and mental alertness.
VITAMIN D (cholecalciferol) – It is also called the sunshine vitamin. It is acquired through sunlight. Vitamin D does not occur in most plants so you must use a supplement or catch the rays. Once you tan, Vitamin D cannot pass through the skin. It is necessary to have Vitamin D to utilize calcium and phosphorus.
VITAMIN K (phytanadione) – This vitamin helps prevent internal bleeding and promotes proper blood clotting. Helps reduce excessive menstrual flow.
CHROMIUM (picolinate) – Helps the body lose fat and keep muscle. It also reduces appetite and helps provide energy. Needed to normalize blood sugar levels.
MOLYBDENUM (sodium molybdate) – This mineral is needed in nitrogen metabolism. It is found in the liver, bones and kidneys. A low intake is associated with mouth and gum disorders. A low intake is also associated with cancer and a lack of this mineral may cause sexual impotence in males.
IODINE (potassium iodide) – Iodine helps to metabolize fat, is needed for thyroid health and prevents goiters. Iodine deficiency has been linked to breast cancer and mental retardation in children. It also promotes healthy hair, skin, and teeth.
BORON (citrate) – This mineral is needed for calcium uptake. It also helps women on estrogen replacement therapy to keep estrogen in the blood longer. Boron retards bone loss in women after menopause.
SELENIUM (selenomethionine) – This works with Vitamin E. They are both antioxidants. It keeps tissue elastic, helps with dandruff, improves circulation, protects against some cancers and alleviates menopausal distress.
CITRUS BIOFLAVONOIDS – Makes Vitamin C work well. The combination of Vitamin C and Bioflavonoids helps strengthen the capillary system. Helps with bruises, bumps and relieves pain. They have an antibacterial affect. In addition to lowering cholesterol, promotes circulation and helps prevent cataracts.
FISH OIL (Omega-3 fatty acids) - Has been shown to decrease blood cholesterol & triglycerides and can also help to prevent blood clots.
PHYTONUTRIENT & ANTIOXIDANT BLEND - Groups of Vitamins, Minerals and Enzymes that help to protect the body from the formation of free radicals, which are groups of atoms that can cause damage to cells, impair the immune system and lead to infections and various degenerative diseases such as heart disease, cancer, high blood pressure and diabetes.
GLUTATHIONE – This is a powerful antioxidant that inhibits the formation of free radicals. Helps prevent the damages of smoking radiation, alcohol and side affects of chemotherapy.
VANADIUM – Needed for cellular metabolism and for the formation of bones and teeth. It plays a role in growth and reproduction and inhibits cholesterol synthesis. A Vanadium deficiency may be linked to cardiovascular and kidney disease, impaired reproductive ability and increased infant mortality. Vanadium has been known to help with reversal and control of diabetes.

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COMPONENT #3
ACTIVANÔ GRAPE SEED EXTRACT – The king of herbs. It supports all body functions and stimulates and improves brain cells.
PEPPERMINT (leaf) – This is one of the most common of household remedies. Peppermint will cleanse the blood and is supportive to the stomach, intestines and muscles.
BROCCOLI, SPINACH AND TOMATO POWDER – An anti-cancer diet would include all of these vegetables.
GARLIC – This is a wonderful antibiotic. It is supportive to all body functions, especially the immune system. It encourages the lymphatic system to get rid of waste and helps cleanse the blood. It strengthens blood vessels and lowers blood pressure. It is recommended in the treatment of arteriosclerosis. It fights both fungal and bacterial infections.
CRANBERRY (fruit powder) – Used to heal bladder infections and kidney stones.
ECHINACEA (standardized extract) – This is an immune enhancer and a natural antibiotic. It is used for flu, infection, tonsillitis, sinus, and digestive tract. It also is an anti-inflammatory and antiviral. It helps you get well and prevents illness. It promotes production of white blood cells.
MILK THISTLE (standardized extract) – Used to restore and protect the liver. It acts as an antioxidant and prevents free radical damage. It also increases membrane strength.
PANEX GINSENG (standardized extract) – Referred to as the king of herbs, it supports all body functions and stimulates and improves brain cells. It helps normalize blood pressure and circulation and reduces cholesterol. Helps the body deal with stress.
GINKGO BILOBA (standardized extract) – It is a powerful antioxidant and improves circulation. It inhibits the clumping of blood platelets which cause heart and artery problems. It improves blood flow to the brain.
GREEN TEA (extract) – A tea from Japan that shows great promise in preventing many cancers. This herb is also an immune system protector.
MANGO (fruit juice concentrate) – An anti-cancer diet would include this food.
SUPPLEMENTAL FACTS: 2 packets

Ingredients	Amount	%RDI
VITAMIN A	20000 IU	400%
VITAMIN C	1000 mg	1666%
VITAMIN D3	120 IU	30%
VITAMIN E	280 IU	933%
VITAMIN K	50 mcg	63%
THIAMINE MONONITRATE (B1)	6 mg	400%
RIBOFLAVIN (B2)	6.8 mg	400%
NIACIN (B3)	50 mg	250%
VITAMIN B6	10 mg	500%
VITAMIN B12	30 mcg	500%
FOLIC ACID	400 mcg	100%
BIOTIN	300 mcg	100%
PANTOTHENIC ACID	30 mg	300%
CALCIUM	820 mg	820%
IODINE	150 mcg	100%
MAGNESIUM	250 mg	62.50%
ZINC	15 mg	100%
SELENIUM	200 mcg	290%
COPPER	2 mg	100%
MANGANESE	5 mg	70%
CHROMIUM	1000 mcg	833%
MOLYBDENUM	23 mcg	30%
BORON	1 mg	*
VANADIUM	1000 mcg	*
CITRUS BIOFLAVONOID COMPLEX	200 mg	*
FISH OIL	2000 mg	*
EPA (Eicosapentaenoic acid from fish oil)	600 mg	*
DHA (Docosahexaenoic acid from fish oil)	400 mg	*
PHYTONUTRIENT & ANTIOXIDANT COMPLEX	855 mg	*
Odorless Garlic (bulb), Broccoli (flower),
Cranberry (fruit), Spinach (leaf), Tomato
(fruit), Panax Ginseng (root) extract 8%
ginsenosides, Green Tea (leaves)
extract 50% polyphenols, Echinacea
Purpurea Angustfolia (whole herb) extract
4% total phenolic compounds, Milk
Thistle (seed) extract 10% Silymarin,
Peppermint (leaf), Mango (fruit) juuice
concentrate, Activin ™ Grape Seed
extract 95% proanthocyanidins,
Glutathione, Ginkgo Biloba (leaf) extract
24% ginkgo flavonglycosides and 6%
terpene lactones.

% Daily Value are based on a 2000 calorie diet.
* % Daily Value not established.

For More Info or to order Click Here